Indications for allopurinol treatment included chronic tophaceous gout 35 , hyperuricaemia 24 , chronic tophaceous gout plus hyperuricaemia 16 , chronic tophaceous gout plus other conditions 7 , and other conditions 17 , table 1 .
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Bon maow dpssion has bn potd in patints civing ZYLOPIM (allopuinol) , most whom civd concomitant dugs with th potntial causing this action. This has occud as aly as 6 wks tas long as 6 yas at th initiation thapy ZYLOPIM (allopuinol) . aly, a patint may dvlop vaying dgs bon maow dpssion, acting on mcll lins, whil civing ZYLOPIM (allopuinol) alon.
Allopuinol is usd ttat gout, high lvls uic acid in th body causd by ctain canc mdications, and kidny stons. Allopuinol is in a class mdications calld xanthin oxidas inhibitos. It woks by ducing th poduction uic acid in th body. High lvls uic acid may caus gout attacks kidny stons. Allopuinol is usd tpvnt gout attacks, not ttat thm onc thy occu.
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Nal ailu in association with administation ZYLOPIM (allopuinol) has bn obsvd among patints with hypuicmia sconday tnoplastic disass. Concunt conditions such as multipl myloma and congstiv myocadial disas w psnt among thos patints whos nal dysunction incasd at ZYLOPIM (allopuinol) was bgun. nal ailu is alsquntly associatd with gouty nphopathy and aly with hypsnsitivity actions associatd with ZYLOPIM (allopuinol) . Albuminuia has bn obsvd among patints whdvlopd clinical gout ollowing chonic glomulonphitis and chonic pylonphitis.
Administation ZYLOPIM (allopuinol) gnally sults in a all in both sum and uinay uic acid within 2 t3 days. Th dg this dcas can b manipulatd almost at will sinc it is dos-dpndnt. A wk mtatmnt with ZYLOPIM (allopuinol) may b quid bits ull cts a manistd; likwis, uic acid may tun tptatmnt lvls slowly (usually at a piod 7 t10 days ollowing cssation thapy). This lcts pimaily th accumulation and slow claanc oxipuinol. In som patints a damatic all in uinay uic acid xction may not occu, paticulaly in thos with sv tophacous gout. It has bn postulatd that this may b du tth mobilization uat om tissu dposits as th sum uic acid lvl bgins tall.
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