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Table 8EVISTA60 mg Once DailyvsPlacebo on Outcomes in Postmenopausal Women at Increased Risk for Major Coronary Events.

In postmarketing spontaneous reportsraloxifene overdose has been reported very rarelyless than 1 out of 10,000

The safety of concomitant use of EVISTA with systemic estrogens has not been established and its use is not recommended.

In a subset of postmenopausal women followed for up to 8 years from randomization in MORE to the end of COREEVISTA60 mg administered once dailyreduced the incidence of invasive breast cancer by 60in women assigned EVISTAN=1355compared with placeboN=1286HR 0.4095CI 0.210.77ARR 1.95 per 1000 women-yearsthis was primarily due to a 65reduction in the incidence of ER-positive invasive breast cancer in the EVISTA group compared with placebo.

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lucrarea de baza in domeniul cercetarii functionalitatii celadrinului este lucrarea lui hessling din anul 2002, care a fost publicata in renumita revista the journal of rheumatology.

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