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Before having surgerytell your doctor or dentist about all the products you useincluding prescription drugsnonprescription drugsand herbal products

To relieve dry mouthsuck onsugarlesshard candy or ice chipschewsugarlessgumdrink wateror use a saliva substitute.

This is not a complete list of side effects and others may occurCall your doctor for medical advice about side effectsYou may report side effects to FDA at 1-800-FDA-1088.

See also PRECAUTIONSDrug InteractionsIn vitro drug metabolism studies reveal that trazodone is a substrate of the cytochrome P450 3A4CYP3A4enzyme and trazodone metabolism can be inhibited by the CYP3A4 inhibitors ketoconazoleritonavirand indinavirThe effect of short-term administration of ritonavir200 mg twice daily4 doseson the pharmacokinetics of a single dose of trazodone50 mghas been studied in 10 healthy subjectsThe C max of trazodone increased by 34the AUC increased 2.4-foldthe half-life increased by 2.2-foldand the clearance decreased by 52Adverse effects including nauseahypotensionand syncope were observed when ritonavir and trazodone were co-administered.

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