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CRP is produced in the liverCRP levels rise in response to inflammation throughout the body.

There is no specific treatment in the event of overdoseIn the event of overdosethe patient should be treated symptomatically and supportive measures instituted as requiredHemodialysis does not significantly enhance clearance of rosuvastatin.

In pregnant rats given 210 and 50 mg/kg/day of rosuvastatin from gestation day 7 through lactation day 21weaningdecreased pup survival occurred at 50 mg/kg/daydose equivalent to 12 times the MRHD of 40 mg/day based body surface area

In children and adolescents 8 to 17 years of age with heterozygous familial hypercholesterolemiathe safety and effectiveness of CRESTOR as an adjunct to diet to reduce total cholesterolLDL-Cand ApoB levels whenafter an adequate trial of diet therapyLDL-C exceeds 190 mg/dL or when LDL-C exceeds 160 mg/dL and there is a positive family history of premature CVD or two or more other CVD risk factorswere established in one controlled trial and in one open-labeluncontrolled trialsee Clinical StudiesThe long-term efficacy of CRESTOR therapy initiated in childhood to reduce morbidity and mortality in adulthood has not been established.

Table 5Effect of Rosuvastatin Coadministration on Systemic Exposure to Other Drugs.

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