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One hundred forty-four hypertensive pediatric patients aged 6 to 16 years were randomized to placebo or to one of three dose levels of metoprolol succinate extended-release tablets 0.

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Metoprolol is metabolized predominantly by CYP2D6an enzyme that is absent in about 8of Caucasianspoor metabolizersand about 2of most other populationsCYP2D6 can be inhibited by a number of drugsPoor metabolizers and extensive metabolizers who concomitantly use CYP2D6 inhibiting drugs will have increasedseveral-foldmetoprolol blood levelsdecreasing metoprolol’s cardioselectivitysee DRUG INTERACTIONS

Before having surgerytell your doctor or dentist about all the products you useincluding prescription drugsnonprescription drugsand herbal products

To reduce the risk of dizziness and lightheadednessget up slowly when rising from a sitting or lying position.

TOPROL-XL tablets are used to treat heart failureIt is used in combination with other medicines to treat your condition.

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in this study, patients treated with metoprolol received the drug both very early intra-venously and during a subsequent 3-month period, while placebo patients received no beta-blocker treatment for this period.

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