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Zyloprim and its primary active metaboliteoxipurinolare eliminated by the kidneysthereforechanges in renal function have a profound effect on dosageIn patients with decreased renal function or who have concurrent illnesses which can affect renal function such as hypertension and diabetes mellitusperiodic laboratory parameters of renal functionparticularly BUN and serum creatinine or creatinine clearanceshould be performed and the patient’s dosage of Zyloprim reassessed.
Skin rashIf you develop a skin rashstop taking this medication and contact your doctorThe skin rash may be the first sign of a serious allergic reaction to the medication.
The most frequent adverse reaction to Zyloprim is skin rashSkin reactions can be severe and sometimes fatalThereforetreatment with Zyloprim should be discontinued immediately if a rash developssee WARNINGSSome patients with the most severe reaction also had feverchillsarthralgiascholestatic jaundiceeosinophilia and mild leukocytosis or leukopeniaAmong 55 patients with gout treated with Zyloprim for 3 to 34 monthsaverage greater than 1 yearand followed prospectivelyRundles observed that 3of patients developed a type of drug reaction which was predominantly a pruritic maculopapular skin eruptionsometimes scaly or exfoliativeHoweverwith current usageskin reactions have been observed less frequently than 1The explanation for this decrease is not obviousThe incidence of skin rash may be increased in the presence of renal insufficiencyThe frequency of skin rash among patients receiving ampicillin or amoxicillin concurrently with Zyloprim has been reported to be increasedsee PRECAUTIONS
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drug interactions in patients receiving purinethol mercaptopurine or imuran azathioprine , the concomitant administration of 300 to 600 mg of zyloprim per day will require a reduction in dose to approximately one third to one fourth of the usual dose of mercaptopurine or azathioprine.