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Other binding proteins may be elevated in serumi.ecorticosteroid binding globulinCBGsex hormone-binding globulinSHBGleading to increased circulating corticosteroid and sex steroidsrespectivelyFree or biologically active hormone concentrations may be decreased.
In the WHI estrogen-alone substudyno overall effect on coronary heart diseaseCHDeventsdefined as nonfatal MIsilent MIor CHD deathwas reported in women receiving estrogen-alone compared to placebo 2see Clinical Studies
PREMARIN Vaginal Cream is not indicated in childrenClinical studies have not been conducted in the pediatric population.
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