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Drinking extra fluids while you are taking zyloprim is recommended.

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For the prevention of uric acid nephropathy during the vigorous therapy of neoplastic diseasetreatment with 600 to 800 mg daily for 2 or 3 days is advisable together with a high fluid intakeOtherwise similar considerations to the above recommendations for treating patients with gout govern the regulation of dosage for maintenance purposes in secondary hyperuricemia.

The reports that the concomitant use of Zyloprim and thiazide diuretics may contribute to the enhancement of allopurinol toxicity in some patients have been reviewed in an attempt to establish a cause-and-effect relationship and a mechanism of causationReview of these case reports indicates that the patients were mainly receiving thiazide diuretics for hypertension and that tests to rule out decreased renal function secondary to hypertensive nephropathy were not often performedIn those patients in whom renal insufficiency was documentedhoweverthe recommendation to lower the dose of Zyloprim was not followedAlthough a causal mechanism and a cause-and-effect relationship have not been establishedcurrent evidence suggests that renal function should be monitored in patients on thiazide diuretics and Zyloprim even in the absence of renal failureand dosage levels should be even more conservatively adjusted in those patients on such combined therapy if diminished renal function is detected.

Zyloprim can lower blood cells that help your body fight infectionsThis can make it easier for you to bleed from an injury or get sick from being around others who are illYour blood may need to be tested oftenVisit your doctor regularly.

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