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CommentsIn clinical studiesmost patients with angina or coronary artery diseaseCADrequired 10 mg orally once a dayThe dosage should be adjusted according to patient responseIn generaltitration should proceed over 7 to 14 daysIf clinically warrantedtitration may proceed more rapidlyprovided the patient is assessed frequently.

Amlodipine may increase systemic exposure of cyclosporine or tacrolimus when co-administeredfrequent monitoring of trough blood levels of cyclosporine and tacrolimus recommendedadjust dose when appropriate.

Limited available data from a published clinical lactation study reports that amlodipine is present in human milk at an estimated median relative infant dose of 4.2no adverse effects of amlodipine on breastfed infant reportedthere is no available information on effects of amlodipine on milk production.

In the CAMELOT and PREVENT studiessee Clinical Studies14.4the adverse event profile was similar to that reported previouslysee abovewith the most common adverse event being peripheral edema.

Extensively metabolized by livertitrate dose slowly with severe hepatic impairment.

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