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As white patients with the gene had a five times greater rate of success in reducing drinking when given naltrexone than did patients without the gene, when used in a protocol of medical management mm , anton et al.

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There was limited evidence of a weak genotoxic effect of naltrexone in one gene mutation assay in a mammalian cell linein the Drosophila recessive lethal assayand in non-specific DNA repair tests with EcoliHoweverno evidence of genotoxic potential was observed in a range of other in vitro testsincluding assays for gene mutation in bacteriayeastor in a second mammalian cell linea chromosomal aberration assayand an assay for DNA damage in human cellsNaltrexone did not exhibit clastogenicity in an in vivo mouse micronucleus assay.

Some side effects can be seriousIf you experience any of these symptoms or those listed in the IMPORTANT WARNING sectioncall your doctor immediately:

It is important for you to keep a written list of all of the prescription and nonprescriptionover-the-countermedicines you are takingas well as any products such as vitaminsmineralsor other dietary supplementsYou should bring this list with you each time you visit a doctor or if you are admitted to a hospitalIt is also important information to carry with you in case of emergencies.

Stop using naltrexone oral and call your doctor at once if you have any of these serious side effects:

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