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20 treated women 55 years of age with 3-week cycles of either oral capecitabine, 1,255 mg m 2 bid for 2 weeks on 1 week off n 61 , or cyclophosphamide with methotrexate and 5-fu cmf n 32 .

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A 5mg folate tablet taken the day after your Methotrexate dose is the recommended treatment to manage these side effectsFolate tablets in 5mg strength can be purchased over the counter in most pharmacies.

Methotrexate self-injectable solution can interact with other medicationsvitaminsor herbs you may be takingAn interaction is when a substance changes the way a drug worksThis can be harmful or prevent the drug from working well.

Do not take these drugs with methotrexateWhen used with methotrexatethese drugs can cause dangerous effects in your bodyExamples of these drugs include:

Maintenanceduring remission15 mg/m2 IM or orally twice a weekAlternate remission dosing2.5 mg/kg IV every 14 days.

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unexpectedly severe, sometimes fatal gastrointestinal toxicity and gi bleeding have been reported with concomitant administration of methotrexate usually in high dosage and some nonsteroidal anti-inflammatory drugs nsaids .

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