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The approach taken in this proposed synthesis of chloramphenicol is largely based on greene s synthesis of paclitaxel, using dihydroxylation methodology proposed by sharpless.

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If your vision becomes blurred for a short while after using chloramphenicoldo not drive and do not use tools until you can see clearly again.

To enhance the stability and obtain a desired 0.5chloramphenicol solution suitable to enter the potential marketseveral attempts such as pH adjustmentmicellar solubilizationcosolvency technique etcwere attemptedHoweveron many occasions tonicity is compromisedOn the other handthe recent trend on these lines is that more stress has to be laid on the issues like stabilitypreservativessterility rather than tonicityAtleast it is practically known that human eye can tolerate hypertonic ophthalmic solutions better than known or thoughtIt has been shown that a range of 0.52 to 2.0sodium chloride equivalency does not cause marked pain response and that a range of 0.7 to 1.5should be acceptable to most personsHoweverunder extreme conditionspreparations as high as 5sodium chloride are also usedThese are used in the treatment of corneal edemaIn certain other cases the therapeutic concentration of the drug will necessitate using what might otherwise be considered an unacceptable tonicityThis is the case with sodium sulfacetamidewhere the isotonic concentration is about 3.5but the drug is used in 10 to 30concentrationsFortunatelythe eye seems to tolerate hypertonic solutions better than hypotonic solutionsKeeping this leverage in mindwe aimed at developing different chloramphenicol ophthalmic drops than those found in the marketThe simplest and most common idea that could come to the mind if tonicity is backlogged is cosolvency techniqueWe performed a literature search if this strategy has been previously mentioned to develop chloramphenicol ophthalmic dropsAs mentioned in the introductiona patent which has been granted to Allerganused the technique of cosolvencyThis is US patent No3,702364on the names of Boghosian M and Wilson Jto Allergan PharmaceuticalsNov1972Based on the patent a product was also launched and marketed by AllerganChloramphenicol 0.5ophthalmic solutionwhich is no longer marketedwas formerly available from AllerganChloropticand AltanaIt contained chloramphenicolchlorobutanolpolyethylene glycol 300polyoxyl 40 stearatesodium hydroxide or hydrochloric acid and purified waterChloramphenicol ophthalmic solution USP is a sterile solution of chloramphenicol containing not less than 90.0and not more than 130.0of the labeled amount of chloramphenicolIt has a pH in the range of 7.0 to 7.5unless it is unbufferedwhen the pH will be between 3.0 and 6.0Its preparation method has been recently published11In this preparation only polyethylene glycol 300 was used as a cosolventHoweverwe aimed at further developing this formulation by incorporating glycerol in the formulation so as to further enhance the stabilityHoweverto begin with the thought of hypertonicity has been there with these formulatorsThusin this study a chloramphenicol hypertonic ophthalmic solution was prepared.

If you need to store chloramphenicol at hometalk with your doctornurseor pharmacist about how to store it.

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Chloramphenicol injection may cause a decrease in the number of certain types of blood cells in the bodyIn some casespeople who experienced this decrease in blood cells later developed leukemiacancer that begins in the white blood cellsYou may experience this decrease in blood cells whether you are being treated with chloramphenicol for a long time or a short timeIf you experience any of the following symptomscall your doctor immediatelypale skinexcessive tirednessshortness of breathdizzinessfast heartbeatunusual bruising or bleedingor signs of infection such as sore throatfevercoughand chills.

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chloramphenicol sodium succinate is available as 1 gram 10 ml per vial powder for intravenous injection form.

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