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Concomitant use of maois and bupropion is contraindicated because there is an increased risk of hypertensive reactions if bupropion is used concomitantly with maois.

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Aplenzinbupropion hydrobromide174 mg orally once/day initiallyequivalent to 150 mg bupropion HClafter 1 weekmay increase to usual target of 348 mg/dayequivalent to 300 mg bupropion HCL)

Extended release tabletsAplenzinInitial dose174 mg orally once a day in the morningequivalent to 150 mg bupropion HClMaintenance doseAfter at least 4 daysthe dose may be increased to 348 mg once a dayequivalent to 300 mg bupropion HClIf there is not adequate improvement after several weeksthe dose may be increased to a maximum of 522 mg once a day in the morningequivalent to 450 mg bupropion HCl

Decreased memory3450 mg/daymay be increased risk with concomitant ECT)

Assess blood pressure before initiating treatment with sustained release formulationand monitor periodically during treatmentrisk of hypertension is increased if sustained release formulation is used concomitantly with MAOIs or other drugs that increase dopaminergic or noradrenergic activityuse caution in patients with cardiovascular disease.

Bupropion may cause seizuresespecially in people with certain medical conditions or when using certain drugsTell your doctor about all of your medical conditions and the drugs you use.

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