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Androgen-producing tumours or an adrenal enzyme defect should be ruled out before prescribing ginette-35 for the treatment of hirsutism.

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Insulin-dependent diabetics without vascular disease can use CPA+EEHoweverit should be remembered that all diabetics are at an increased risk of arterial disease and this should be considered when prescribing COCs or CPA+EEDiabetics with existing vascular disease are contraindicated from using CPA+EE.

GINETTE 35CPA+EEblocks androgen receptorsIt also reduces androgen synthesis both by negative feedback effect on the hypothalamo-pituitary-ovarian systems and by the inhibition of androgen-synthesizing enzymes.

The following conditions have been reported to occur or deteriorate with both pregnancy and use of a COC or oestrogen/progestogen combinations like CPA+EEConsideration should be given to stopping CPA+EE if any of the following occur during use:

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