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Many other medicines can interact with COUMADIN and affect the dose you need or increase COUMADIN side effectsDo not change or stop any of your medicines or start any new medicines before you talk to your healthcare provider.

Frequency not reportedUnexplained decrease in hematocrithemoglobin decreasedRef]

There were approximately four times as many major bleeding episodes in the two groups receiving warfarin than in the group receiving aspirin aloneMajor bleeding episodes were not more frequent among patients receiving aspirin plus warfarin than among those receiving warfarin alonebut the incidence of minor bleeding episodes was higher in the combined therapy group.

The intravenous dose of COUMADIN is the same as the oral doseAfter reconstitutionadminister COUMADIN for injection as a slow bolus injection into a peripheral vein over 1 to 2 minutes.

Coumadin has no direct effect on an established thrombusnor does it reverse ischemic tissue damageOnce a thrombus has occurredhoweverthe goals of anticoagulant treatment are to prevent further extension of the formed clot and to prevent secondary thromboembolic complications that may result in serious and possibly fatal sequelae.

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