Colchicine interferes with microtubule dynamics, promoting microtubule depolymerization in cells wilson and jordan, 1994 .
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Colchicine is a substrate of the efflux transporter P-glycoproteinP-gpand the CYP3A4 metabolizing enzymeFatal drug interactions have been reported when colchicine is administered with clarithromycina dual inhibitor of CYP3A4 and P-glycoproteinToxicities have also been reported when colchicine is administered with inhibitors of CYP3A4 that may not be potent inhibitors of P-gpe.ggrapefruit juiceerythromycinverapamilor inhibitors of P-gp that may not be potent inhibitors of CYP3A4e.gcyclosporine
Co-administration with P-gp inhibitors and/or moderate or strong CYP3A4 inhibitors will increase the exposure to colchicinewhich may lead to colchicine induced toxicity including fatalitiesIf treatment with a P-gp inhibitor or a moderate or strong CYP3A4 inhibitor is required in patients with normal renal and hepatic functiona reduction in colchicine dosage or interruption of colchicine treatment is recommendedsee section 4.5
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there is no difference between men and women in the pharmacokinetic disposition of colchicine.