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Take this medication by mouth without food as directed by your doctorusually twice dailyat least 30 minutes before or 2 hours after breakfast and dinnerThe dosage is based on your medical conditionresponse to treatmentand other medications you may be takingBe sure to tell your doctor and pharmacist about all the products you useincluding prescription drugsnonprescription drugsand herbal products

Read the Patient Information Leaflet if available from your pharmacist before you start taking cilostazol and each time you get a refillIf you have any questionsask your doctor or pharmacist.

The total pharmacologic activity of cilostazol and its metabolites was similar in subjects with mild to moderate renal impairment and in healthy subjectsSevere renal impairment increases metabolite levels and alters protein binding of the parentThe expected pharmacologic activityhoweverbased on plasma concentrations and relative PDE III inhibiting potency of parent drug and metabolitesappeared little changedPatients on dialysis have not been studiedbutit is unlikely that cilostazol can be removed efficiently by dialysis because of its high protein binding9598

Pletal is indicated for the reduction of symptoms of intermittent claudicationas demonstrated by an increased walking distance.

Based on its mechanism of actioncilostazol may induce tachycardiapalpitationtachyarrhythmia and/or hypotensionThe increase in heart rate associated with cilostazol is approximately 5 to 7 bpmin patients at risk this consequently may induce angina pectoris.

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