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Promethazine is known to cause euphoria, so if you are having cough syrup on daily basis, your mind will need it more, rather than want it.

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Rectal25 mg onceAn additional doseup to 50 mgmay be administered to achieve the desired clinical effect.

Promethazine is in a group of drugs called phenothiazinesFEEN-oh-THYE-a-zeensIt works by changing the actions of chemicals in your brainPromethazine also acts as an antihistamineIt blocks the effects of the naturally occurring chemical histamine in your body.

Take promethazine exactly as prescribed by your doctorFollow all directions on your prescription labelYour doctor may occasionally change your dose to make sure you get the best resultsDo not take this medicine in larger or smaller amounts or for longer than recommended.

How often you take this medicine and the timing of your dose will depend on the condition being treated.

If the suppository feels softhold it under coldrunning water for 1 minuteRemove the wrapperDip the tip of the suppository in waterLie down on your left side and raise your right knee to your chestA left-handed person should lie on the right side and raise the left kneeUsing your fingerinsert the suppository into the rectumabout 1/2 to 1 inch1.25 to 2.5 centimetersin children who are 2 years of age older and 1 inch2.5 centimetersin adultsHold it in place for a few momentsStand up after about 15 minutesWash your hands thoroughly and resume your normal activities.

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dangers arise in higher dosages because promethazine is a depressant of the central nervous system and codeine is a respiratory depressant.

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