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You should not change your dose or stop using bupropion suddenlyunless you have a seizure while taking this medicineStopping suddenly can cause unpleasant withdrawal symptoms.

Events are further categorized by body system and listed in order of decreasing frequency according to the following definitions of frequencyFrequent adverse events are defined as those occurring in at least 1/100 patientsInfrequent adverse events are those occurring in 1/100 to 1/1,000 patientswhile rare events are those occurring in less than 1/1,000 patients.

Metabolic and NutritionalInfrequent were edema and peripheral edemaAlso observed was glycosuria.

Plots of the steady-state plasma concentrations of bupropion over a 24-hour period for the IRSRand XL formulations of bupropion are presented in Figure 1data on fileGlaxoSmithKlineResearch Triangle ParkN.CWith steady-state dosing at 300 mg/dayboth the SR and XL formulationsrelative to the IR formulationdeliver an equivalent amount of bupropionAUCand do so while producing C max similar to or somewhat less than those seen with the IR formulationSince some adverse events are believed to be associated with C maxit is worth noting that the SR and XL formulations decrease the number of daily exposures of peak plasma levels to twice and once dailyrespectivelyImportantlytime to C maxT maxis prolonged with the SR3 hoursand XL formulations5 hoursrelative to the IR formulation2 hoursBoth the prolongation of T max and the decrease in the number of peak plasma levels may result in better tolerabilityalthough this has not been formally evaluatedWith once-daily dosing of the XL formulation in the morningplasma bupropion concentration levels are lower during evening hours compared to the SR formulationFigure 2data on fileGlaxoSmithKlineResearch Triangle ParkN.CThis may result in a lower rate of insomniaan adverse event that has been reported to be correlated with plasma concentrations5 The extended release of bupropion seen with the XL formulation is achieved by a moisture-barrier coating and a control-releasing coating surrounding a tablet core containing bupropionThe integrity of the delivery matrix is essential to providing an extended-release ratechewingcuttingor crushing bupropion XL tablets would disrupt the delivery matrixresulting in immediate release of bupropionwhich could cause significant adverse events.

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