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Increase or decrease in weightglucose intoleranceedemaarthralgiasleg crampschanges in libidourticariaexacerbation of asthmaincreased triglycerideshypersensitivity.

In the WHI estrogen-alone substudya statistically significant increased risk of stroke was reported in women 50 to 79 years of age receiving daily CE0.625 mgcompared to women receiving placebo45 versus 33 per 10,000 women-yearsThe increase in risk was demonstrated in year one and persistedSubgroup analyses of women 50 to 59 years of age suggest no increased risk of stroke for those women receiving CE0.625 mgversus those receiving placebo18 versus 21 per 10,000 women-years

Your doctor should check your progress on a regular basis to determine whether you should continue this treatmentSelf-examine your breasts for lumps on a monthly basisand have regular mammograms.

There arehoweverpossible risks that may be associated with the use of progestins with estrogens compared to estrogen-alone regimensThese include an increased risk of breast cancer.

Estrogens may cause some degree of fluid retentionWomen with conditions that might be influenced by this factorsuch as cardiac or renal dysfunctionwarrant careful observation when estrogen-alone is prescribed.

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