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ThusMAOIs appear to be an alternative antidepressant treatmentand may be particularly effective in refractory depressionatypical depressionmelancholiaand possibly bipolar depressionUnfortunatelyside effects and dietary issues may limit its general usefulnessRecentlyselegilinea MAOI-Bwas developed as a transdermal patchEMSAMin an attempt to develop a more user-friendly MAOIThe availability of a new MAOIEMSAMthat is an easily applied transdermal antidepressant preparation should provide an antidepressant that is easier to administer and more tolerable than oral MAOI preparationsThis is clinically relevant since the use of oral MAOIs is clearly limited by their potential side effectsas seen in the STAR*D projectoral MAOIs are not well-tolerated by a significant subgroupleading to limitation of dosage and/or early discontinuation20.
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Do not use EMSAM if youtake certain medicines includingselective serotonin reuptake inhibitorsSSRIssuch as fluoxetinesertralineor paroxetineserotonin and norepinephrine reuptake inhibitorsSNRIsuch as venlafaxine or duloxetineclomipramine or imipraminetricyclic antidepressantsmeperidinetramadolmethadonepentazocinepropoxypheneopioid medicinesdextromethorphanor carbamazepine are less than 12 years of age have a tumor on your adrenal gland called a pheochromocytoma Ask your health care professional or pharmacist if you are not sure if you take these medicines.
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