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In mic, th 50% lthal dos (LD 50 ) is 160 mg\/kg givn intapitonally (IP) with daths dlayd up t5 days and 700 mg\/kg oally (PO) (appoximatly 140 tims th usual human dos) with daths dlayd up t3 days. In ats, th acut LD50 is 750 mg\/kg IP and 6000 mg\/kg PO (appoximatly 1200 tims th human dos).<\/p>\n

It has bn potd that ZYLOPIM (allopuinol) polongs th hal-li th anticoagulant, dicumaol. Th clinical basis this dug intaction has not bn stablishd but should b notd whn ZYLOPIM (allopuinol) is givn tpatints alady on dicumaol thapy.<\/p>\n

A w cass vsibl clinical hpatotoxicity hav bn notd in patints taking ZYLOPIM (allopuinol) , and in som patints, asymptomatic iss in sum alkalin phosphatas sum tansaminas hav bn obsvd. I anoxia, wight loss, puitus dvlop in patints on ZYLOPIM (allopuinol) , valuation liv unction should b pat thi diagnostic wokup. In patints with p-xisting liv disas, piodic liv unction tsts a commndd duing th aly stags thapy.<\/p>\n

Appoximatly 20% th ingstd ZYLOPIM (allopuinol) is xctd in th cs. Bcaus its apid oxidation toxipuinol and a nal claanc at appoximatly that glomula iltation at, ZYLOPIM (allopuinol) has a plasma hal-li about 1 t2 hous. Oxipuinol, howv, has a long plasma hal-li (appoximatly 15 hous) and thctiv xanthin oxidas inhibition is maintaind ov a 24-hou piod with singl daily doss ZYLOPIM (allopuinol) . Whas ZYLOPIM (allopuinol) is clad ssntially by glomula iltation, oxipuinol is absobd in th kidny tubuls in a mann simila tth absoption uic acid.<\/p>\n

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