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Clement and colleagues reported the effects of intravenous dapoxetine on the emission and ejection phases of ejaculation using p-chloroamphetaminePCAinduced ejaculation as an experimental model of ejaculation in anesthetized ratsClement et al2006Intraseminal vesicle pressure and electromyograms of bulbospongiosus muscles were used as physiological markers of the emission and ejection phases respectivelyAt all dosesdapoxetine significantly reduced the proportion of rats displaying PCA-induced ejaculation in a dose-dependent mannerfrom 78of rats with vehicle to 3322and 13of rats following intravenous dapoxetine 13 and 10 mg\/kgrespectivelyDapoxetine significantly decreased the AUC of PCA-induced intraseminal vesicle pressure increases and bulbospongiosus muscle contractile bursts by 78at all dosesby 91following dapoxetine 1 and 10 mg\/kgand by 85following dapoxetine 3 mg\/kg.<\/p>\n

Plasma concentration profiles of dapoxetine after administration of a single dose or multiple doses of dapoxetine 30 mgaand dapoxetine 60 mgbModi et al2006<\/p>\n

PE may be treated with sex therapymedicationsor a combination of these approachesDapoxetinea selective serotonin reuptake inhibitorSSRIis the only oral medication developed to treat PEIt is approved in 60 countries.<\/p>\n

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