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Applies to verapamiloral capsule extended releaseoral capsule extended release 24 hroral tabletoral tablet extended releaseoral tablet extended release 24 hr.<\/p>\n

In healthy manorally administered ISOPTIN undergoes extensive metabolism in the liverTwelve metabolites have been identified in plasmaall except norverapamil are present in trace amounts onlyNorverapamil can reach steadystate plasma concentrations approximately equal to those of verapamil itselfThe cardiovascular activity of norverapamil appears to be approximately 20that of verapamilApproximately 70of an administered dose is excreted as metabolites in the urine and 16or more in the feces within 5 daysAbout 3to 4is excreted in the urine as unchanged drugApproximately 90is bound to plasma proteinsIn patients with hepatic insufficiencymetabolism of immediate release verapamil is delayed and elimination half-life prolonged up to 14 to 16 hourssee PRECAUTIONSthe volume of distribution is increased and plasma clearance reduced to about 30of normalVerapamil clearance values suggest that patients with liver dysfunction may attain therapeutic verapamil plasma concentrations with one third of the oral daily dose required for patients with normal liver function.<\/p>\n

Lab and\/or medical testssuch as liver functionshould be done while you are taking this medicationKeep all medical and lab appointmentsConsult your doctor for more details.<\/p>\n

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