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Plasma concentrations of metronidazole are proportional to the administered doseOral administration of 250 mg500 mgor 2,000 mg produced peak plasma concentrations of 6 mcg\/mL12 mcg\/mLand 40 mcg\/mLrespectivelyStudies reveal no significant bioavailability differences between males and femaleshoweverbecause of weight differencesthe resulting plasma levels in males are generally lower.<\/p>\n
Before using this medicationtell your doctor or pharmacist your medical historyespecially ofliver diseasekidney diseasecertain blood disorderslow blood cell counts<\/p>\n
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In patients stabilized on relatively high doses of lithiumshort-term metronidazole therapy has been associated with elevation of serum lithium andin a few casessigns of lithium toxicitySerum lithium and serum creatinine levels should be obtained several days after beginning metronidazole to detect any increase that may precede clinical symptoms of lithium intoxication.<\/p>\n
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