Information about Viramune.<\/h2>\n<\/p>\n

Most of the experience with Viramune is in combination with nucleoside reverse transcriptase inhibitorsNRTIsThe choice of a subsequent therapy after Viramune should be based on clinical experience and resistance testingsee section 5.1<\/p>\n

Currently available data on pregnant women indicate no malformative or foetoneonatal toxicityTo date no other relevant epidemiological data are availableNo observable teratogenicity was detected in reproductive studies performed in pregnant rats and rabbitssee section 5.3There are no adequate and well-controlled studies in pregnant womenCaution should be exercised when prescribing nevirapine to pregnant womensee section 4.4As hepatotoxicity is more frequent in women with CD4 cell counts above 250 cells\/mm 3 with detectable HIV-1 RNA in plasma50 or more copies\/mlthese conditions should be taken in consideration on therapeutic decisionsee section 4.4There is not enough evidence to substantiate that the absence of an increased risk for toxicity seen in pre-treated women initiating nevirapine with an undetectable viral loadless than 50 copies\/ml of HIV-1 in plasmaand CD4 cell counts above 250 cells\/mm 3 also applies to pregnant womenAll the randomised studies addressing this issue specifically excluded pregnant womenand pregnant women were under-represented in cohort studies as well as in meta-analyses.<\/p>\n

It is not recommended to co-administer fosamprenavir and Viramune if fosamprenavir is not co-administered with ritonavirsee section 4.4<\/p>\n

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patients, particularly women, with increased cd4 cell count at initiation of viramune therapy 250 cells mm 3 in women and 400 cells mm 3 in men are atsubstantially higher risk for development of symptomatic hepatic events, oftenassociated with rash.