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After an intravenous dose of 1 gthe plasma concentration time curve shows a triexponential decay with a half-life of about 2 hours for the terminal elimination phaseThe initial volume of distribution is about 9 to 12 litersUrinary excretion is the main route of elimination via glomerular filtrationOverall renal clearance is equal to overall plasma clearance110 to 116 mL\/minand more than 95of the dose is excreted in the urine as unchanged drugExcretion of tranexamic acid is about 90at 24 hours after intravenous administration of 10 mg per kg body weight.<\/p>\n

Convulsions have been reported in association with tranexamic acid treatmentparticularly in patients receiving tranexamic acid during cardiovascular surgery and in patients inadvertently given tranexamic acid into the neuraxial system.<\/p>\n

Convulsions have been reported in association with tranexamic acid treatmentparticularly in patients receiving tranexamic acid during cardiovascular surgery and in patients inadvertently given tranexamic acid into the neuraxial system.<\/p>\n

This medication is used short-term in people with a certain type of bleeding disorderhemophiliato prevent and reduce bleeding from having a tooth pulledextractionIt is also used in people with other high-risk bleeding conditions to control bleeding at such times as after surgery or an injuryduring heavy nosebleedsor during heavy menstrual bleeding.<\/p>\n

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