For the prevention of uric acid nephropathy during the vigorous therapy of neoplastic diseasetreatment with 600 to 800 mg daily for 2 or 3 days is advisable together with a high fluid intakeOtherwise similar considerations to the above recommendations for treating patients with gout govern the regulation of dosage for maintenance purposes in secondary hyperuricemia.
The reports that the concomitant use of Zyloprim and thiazide diuretics may contribute to the enhancement of allopurinol toxicity in some patients have been reviewed in an attempt to establish a cause-and-effect relationship and a mechanism of causationReview of these case reports indicates that the patients were mainly receiving thiazide diuretics for hypertension and that tests to rule out decreased renal function secondary to hypertensive nephropathy were not often performedIn those patients in whom renal insufficiency was documentedhoweverthe recommendation to lower the dose of Zyloprim was not followedAlthough a causal mechanism and a cause-and-effect relationship have not been establishedcurrent evidence suggests that renal function should be monitored in patients on thiazide diuretics and Zyloprim even in the absence of renal failureand dosage levels should be even more conservatively adjusted in those patients on such combined therapy if diminished renal function is detected.
Zyloprim can lower blood cells that help your body fight infectionsThis can make it easier for you to bleed from an injury or get sick from being around others who are illYour blood may need to be tested oftenVisit your doctor regularly.
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it does not include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to zyloprim.
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Zyloprim and its primary active metaboliteoxipurinolare eliminated by the kidneysthereforechanges in renal function have a profound effect on dosageIn patients with decreased renal function or who have concurrent illnesses which can affect renal function such as hypertension and diabetes mellitusperiodic laboratory parameters of renal functionparticularly BUN and serum creatinine or creatinine clearanceshould be performed and the patient’s dosage of Zyloprim reassessed.
Skin rashIf you develop a skin rashstop taking this medication and contact your doctorThe skin rash may be the first sign of a serious allergic reaction to the medication.
The most frequent adverse reaction to Zyloprim is skin rashSkin reactions can be severe and sometimes fatalThereforetreatment with Zyloprim should be discontinued immediately if a rash developssee WARNINGSSome patients with the most severe reaction also had feverchillsarthralgiascholestatic jaundiceeosinophilia and mild leukocytosis or leukopeniaAmong 55 patients with gout treated with Zyloprim for 3 to 34 monthsaverage greater than 1 yearand followed prospectivelyRundles observed that 3of patients developed a type of drug reaction which was predominantly a pruritic maculopapular skin eruptionsometimes scaly or exfoliativeHoweverwith current usageskin reactions have been observed less frequently than 1The explanation for this decrease is not obviousThe incidence of skin rash may be increased in the presence of renal insufficiencyThe frequency of skin rash among patients receiving ampicillin or amoxicillin concurrently with Zyloprim has been reported to be increasedsee PRECAUTIONS
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drug interactions in patients receiving purinethol mercaptopurine or imuran azathioprine , the concomitant administration of 300 to 600 mg of zyloprim per day will require a reduction in dose to approximately one third to one fourth of the usual dose of mercaptopurine or azathioprine.
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