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An exaggerated use washing test on the sensitive antecubital skin of 10 subjects twice daily for five consecutive days showed that the irritancy potential of ketoconazole 2shampoo was significantly less than that of 2.5selenium sulfide shampoo.

Co-administration of ketoconazole with the following agents was shown or is expected to result in increased exposure to these drugsThereforecareful monitoring of plasma concentrations or adverse events of these drugs is recommendedAdjustment of dosage of these drugs may be needed.

Call your doctor at once if you have any signs of liver damagesuch as nauseaupper stomach painitchingtired feelingloss of appetitedark urineclay-colored stoolsor jaundiceyellowing of the skin or eyes

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Ketoconazole can prolong the QT intervalCo-administration of the following drugs with ketoconazole is contraindicateddofetilidequinidinepimozideand cisaprideKetoconazole can cause elevated plasma concentrations of these drugs which may prolong the QT intervalsometimes resulting in life-threatening ventricular dysrhythmias such as torsades de pointes.

Because severe hypoglycemia has been reported in patients concomitantly receiving oral miconazolean imidazoleand oral hypoglycemic agentssuch a potential interaction involving the latter agents when used concomitantly with ketoconazole tabletsan imidazolecannot be ruled out.

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