Information about Lariam.

Two metabolites have been identified in humansThe main metabolite2,8bistrifluoromethyl-4-quinoline carboxylic acidis inactive in Plasmodium falciparumIn a study in healthy volunteersthe carboxylic acid metabolite appeared in plasma 2 to 4 hours after a single oral doseMaximum plasma concentrationswhich were about 50higher than those of mefloquinewere reached after 2 weeksThereafterplasma levels of the main metabolite and mefloquine declined at a similar rateThe area under the plasma concentration-time curveAUCof the main metabolite was 3 to 5 times larger than that of the parent drugThe other metabolitean alcoholwas present in minute quantities only.

In patients taking an anticonvulsantegvalproic acidcarbamazepinephenobarbital or phenytointhe concomitant use of Lariammefloquinemay reduce seizure control by lowering the plasma levels of the anticonvulsantThereforepatients concurrently taking antiseizure medication and Lariammefloquineshould have the blood level of their antiseizure medication monitored and the dosage adjusted appropriatelysee PRECAUTIONS

Liver problemsnauseaupper stomach painitchingtired feelingloss of appetitedark urineclay-colored stoolsjaundiceyellowing of the skin or eyes

If you are taking Lariam to prevent malariayou should also take steps to avoid mosquito bitesSome information on how to avoid bites is given belowThis is important as no medicine can be 100guaranteed to protect you against malaria.

Please seek medical help immediately if you experience serious mental problems while taking LariamLariam should be stopped immediately and replaced with another medicine to prevent malaria.

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Information about Lariam.

You also should not use Lariam to prevent malaria if you have a recent history of:

If you stop taking the medicine early for any reasoncontact a healthcare professional about another form of malaria prevention.

The potential case against the British Army appears to hinge on the extent to which it took sufficient measures to screen soldiers to check for such signs and symptoms.

NotePatients with acute Pvivax malariatreated with Lariammefloquineare at high risk of relapse because Lariammefloquinedoes not eliminate exoerythrocytichepatic phaseparasitesTo avoid relapseafter initial treatment of the acute infection with Lariammefloquinepatients should subsequently be treated with an 8-aminoquinoline derivativeegprimaquine

A mild to serious potential life-threatening allergic reactionanaphylaxisto Lariam or any of its ingredients with symptoms such as difficulty in breathingswollen tongueitching and severe rash severe changes in texture and appearance of the skinespecially serious blistering and peeling that affects the moutheyes and genitalsStevens Johnson syndromefitsseizures or convulsionsheart problems e.gsevere changes in heartbeatincluding poundingracing or skipped beatspalpitationsinflammation of the lungsalso known as pneumonitisThis is a seriouspotentially life-threatening allergic reaction in the lungs which may cause feverchillscoughshortness of breath or chest painsevere liver problems which might be demonstrated by a transient increase in your liver enzymes shown by blood tests or other symptoms such as tenderfirm or possibly enlarged liverjaundiceyellowing of skin/eyesdark urinelight coloured stools and generalised itchiness.

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some current and former troops sent to iraq claim that lariam has provoked violent and dangerous behavior.