Information about Kytril.

During clinical trials325 patients 65 years of age or older received KYTRILgranisetronTablets298 were 65 to 74 years of ageand 27 were 75 years of age or olderEfficacy and safety were maintained with increasing age.

This drug may make you dizzy or drowsyAlcohol or marijuana can make you more dizzy or drowsyDo not driveuse machineryor do anything that needs alertness until you can do it safelyLimit alcoholic beveragesTalk to your doctor if you are using marijuana.

Kytril is an anti-emetica medicine that prevents nausea and vomitingIt is used to prevent nausea and vomiting following treatments for cancer such as chemotherapy and radiotherapy.

PRECAUTIONSBefore taking granisetrontell your doctor or pharmacist if you are allergic to itor if you have any other allergiesThis product may contain inactive ingredientswhich can cause allergic reactions or other problemsTalk to your pharmacist for more details.Before using this medicationtell your doctor or pharmacist your medical history.This drug may make you dizzy or drowsyDo not driveuse machineryor do any activity that requires alertness until you are sure you can perform such activities safelyLimit alcoholic beverages.Granisetron may cause a condition that affects the heart rhythmQT prolongationQT prolongation can infrequently result in seriousrarely fatalfast/irregular heartbeat and other symptomssuch as severe dizzinessfaintingthat need medical attention right away.The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongationBefore using granisetrontell your doctor or pharmacist of all the drugs you take and if you have any of the following conditionscertain heart problemsheart failureslow heartbeatQT prolongation in the EKGfamily history of certain heart problemsQT prolongation in the EKGsudden cardiac deathLow levels of potassium or magnesium in the blood may also increase your risk of QT prolongationThis risk may increase if you use certain drugssuch as diureticswater pillsor if you have conditions such as severe sweatingdiarrheaor vomitingTalk to your doctor about using granisetron safely.Older adults may be more sensitive to the side effects of this drugespecially QT prolongationsee aboveThis medication should be used only when clearly needed during pregnancyDiscuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milkConsult your doctor before breast-feeding.

There is no specific treatment for granisetron hydrochloride overdosageIn case of overdosagesymptomatic treatment should be givenOverdosage of up to 38.5 mg of granisetron hydrochloride injection has been reported without symptoms or only the occurrence of a slight headache.

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During clinical trials325 patients 65 years of age or older received KYTRILgranisetronTablets298 were 65 to 74 years of ageand 27 were 75 years of age or olderEfficacy and safety were maintained with increasing age.

It is not known whether granisetron is excreted in human milkBecause many drugs are excreted in human milkcaution should be exercised when KYTRILgranisetronis administered to a nursing woman.

STORAGEFor oral tabletsStore at room temperature between 59-86 degrees F15-30 degrees CFor oral solutionStore at room temperature at 77 degrees F25 degrees CBrief storage between 59-86 degrees F15-30 degrees Cis permittedStore bottle in an upright position.Store away from light and moistureDo not store in the bathroomKeep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do soProperly discard this product when it is expired or no longer neededConsult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Granisetron does not induce or inhibit the cytochrome P-450 drug-metabolizing enzyme system in vitroThere have been no definitive drug-drug interaction studies to examine pharmacokinetic or pharmacodynamic interaction with other drugshoweverin humansKYTRILgranisetronInjection has been safely administered with drugs representing benzodiazepinesneurolepticsand anti-ulcer medications commonly prescribed with antiemetic treatmentsKYTRILgranisetronInjection also does not appear to interact with emetogenic cancer chemotherapiesBecause granisetron is metabolized by hepatic cytochrome P-450 drug-metabolizing enzymesinducers or inhibitors of these enzymes may change the clearance andhencethe half-life of granisetronNo specific interaction studies have been conducted in anesthetized patientsIn additionthe activity of the cytochrome P-450 subfamily 3A4involved in the metabolism of some of the main narcotic analgesic agentsis not modified by KYTRILgranisetronin vitro.

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