Taking this medicine with other drugs that make you sleepy can worsen this effectAsk your doctor before taking trazodone with a sleeping pillnarcotic pain medicinemuscle relaxeror medicine for anxietydepressionor seizures.
Do not stop using trazodone suddenlyor you could have unpleasant withdrawal symptomsAsk your doctor how to safely stop using this medicine.
Frequency not reportedDelayed urine flowearly menseshematuriaimpotenceincreased urinary frequencymicturition disordersmissed periodspriapismretrograde ejaculation.
This medication passes into breast milkConsult your doctor before breast-feeding.
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To relieve dry mouthsuck onsugarlesshard candy or ice chipschewsugarlessgumdrink wateror use a saliva substitute.
This is not a complete list of side effects and others may occurCall your doctor for medical advice about side effectsYou may report side effects to FDA at 1-800-FDA-1088.
See also PRECAUTIONSDrug InteractionsIn vitro drug metabolism studies reveal that trazodone is a substrate of the cytochrome P450 3A4CYP3A4enzyme and trazodone metabolism can be inhibited by the CYP3A4 inhibitors ketoconazoleritonavirand indinavirThe effect of short-term administration of ritonavir200 mg twice daily4 doseson the pharmacokinetics of a single dose of trazodone50 mghas been studied in 10 healthy subjectsThe C max of trazodone increased by 34the AUC increased 2.4-foldthe half-life increased by 2.2-foldand the clearance decreased by 52Adverse effects including nauseahypotensionand syncope were observed when ritonavir and trazodone were co-administered.
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