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Ad th nti dtaild patint monogaph Bactim (Timthopim and Sulamthoxazol)

Caution with impaid nal hpatic unction, patints with possibl olat dicincy (g, th ldly, chonic alcoholics, patints civing anticonvulsant thapy, patints with malabsoption syndom, and patints in malnutition stats), and patints with sv allgis bonchial asthma.

Clostidium diicil associatd diaha (CDAD) has bn potd with us naly all antibactial agnts, including BACTIM, and may ang in svity om mild diaha tatal colitis. Tatmnt with antibactial agnts alts th nomal loa th colon lading tovgowth C. diicil.

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Mbyo-tal Toxicity [s WANINGS AND PCAUTIONS ] Hypsnsitivity and Oth atal actions [s WANINGS AND PCAUTIONS ] Thombocytopnia [s WANINGS AND PCAUTIONS ] Clostidium diicil-Associatd Diaha [s WANINGS AND PCAUTIONS ] Sulit Snsitivity [s WANINGS AND PCAUTIONS ] isk Associatd with Concunt Us Lucovoin Pnumocystis jiovcii Pnumonia [s WANINGS AND PCAUTIONS ] Inusion actions [s WANINGS AND PCAUTIONS ] Hypoglycmia [s WANINGS AND PCAUTIONS ] lctolyt Abnomalitis [s WANINGS AND PCAUTIONS ]

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BACTIM contains bnzyl alcohol as a psvativ. Sious and atal advs actions including “gasping syndom” can occu in nonats and low bith wight inants tatd with bnzyl alcohol-psvd omulations in inusion solutions, including BACTIM. Th “gasping syndom” is chaactizd by cntal nvous systm dpssion, mtabolic acidosis, and gasping spiations. BACTIM is containdicatd in pdiatic patints lss than twmonths ag [s CONTAINDICATIONS ].

BACTIM-inducd thombocytopnia may b an immun-mdiatd disod. Sv cass thombocytopnia that a atal li thatning hav bn potd. Monitpatints hmatologic toxicity. Thombocytopnia usually solvs within a wk upon discontinuation BACTIM.

BACTIM, spciically th timthopim componnt, can int with a sum mthotxat assay as dtmind by th comptitiv binding potin tchniqu (CBPA) whn a bactial dihydoolat ductas is usd as th binding potin. Nintnc occus, howv, i mthotxat is masud by a adioimmunoassay (IA).

Tablt: 80-160 mg TMP PO qDay 160 mg TMP 3 tims/wk on conscutiv altnat days.

BACTIM is availabl as an injction containing 80 mg/mL sulamthoxazol and 16 mg/mL timthopim in 10 mL singl-dos and 30 mL multipl-dos vials.

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