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Plasma concentrations of metronidazole are proportional to the administered doseOral administration of 250 mg500 mgor 2,000 mg produced peak plasma concentrations of 6 mcg/mL12 mcg/mLand 40 mcg/mLrespectivelyStudies reveal no significant bioavailability differences between males and femaleshoweverbecause of weight differencesthe resulting plasma levels in males are generally lower.
Before using this medicationtell your doctor or pharmacist your medical historyespecially ofliver diseasekidney diseasecertain blood disorderslow blood cell counts
For acute intestinal amebiasisacute amebic dysentery750 mg orally three times daily for 5 to 10 days.
In patients stabilized on relatively high doses of lithiumshort-term metronidazole therapy has been associated with elevation of serum lithium andin a few casessigns of lithium toxicitySerum lithium and serum creatinine levels should be obtained several days after beginning metronidazole to detect any increase that may precede clinical symptoms of lithium intoxication.
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